Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Nectin-4 Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms PVRL4; Nectin 4; Ig superfamily receptor LNIR; Poliovirus receptor related protein 4; PRR4; LNIR; Nectin4 Accession Q8R007 1 Amino Acid Sequence Gly31 Ser347, with C hIgG1 Fc Expression System HEK293 Molecular Weight 70 73kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution
Product Specification
| Species | Mouse |
| Synonyms | PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR; Nectin4 |
| Accession | Q8R007-1 |
| Amino Acid Sequence | Gly31-Ser347, with C-hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 70-73kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Noyce Ryan S. et al. (2012) Nectin 4 is the epithelial cell receptor for measles virus. Trends Microbiol. 20(9): 429-439. |
Background
Nectin-4, also known as poliovirus like receptor 4 (PVRL4), is a newly discovered cell adhesion molecule belonging to the Nectin family, which has four members: Nectin-1, Nectin-2, Nectin-3 and Nectin-4. Nectin protein had three consecutive immunoglobulin-like domains outside the cell, namely, the Ig-V domain at the N terminal and two Ig-C2 domains at the C terminal. Nectin-4 is mainly expressed in the placenta, in normal human tissues including skin, bladder, salivary glands, esophagus, breast and stomach, and abnormally expressed on the surface of various cancer cells such as breast cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer. Nectin-4 promotes tumor cell proliferation, differentiation, migration, and invasion through activation of PI3K/Akt pathway. In some cancers, such as urothelial carcinoma, high expression of Nectin-4 can promote tumor cell proliferation and angiogenesis, and reduce cancer cell apoptosis. Studies have shown that Nectin-4, as a novel ligand of TIGIT, can inhibit the activity of natural killer cells. These suggest that Nectin-4 may be a potential target for cancer therapy.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy